In Vitro Anticancer Efficacy Testing

For more than three decades, Southern Research has provided cell biology and other in vitro pharmacology-based services to the pharmaceutical industry and the National Cancer Institute. The services we provide are instrumental in drug development and can provide insight for designing in vivo anticancer efficacy studies.

We work closely with clients to develop custom assays and experimental plans that meet our clients' specific research needs. In state-of-the-art laboratories, research is conducted by highly qualified technicians utilizing well defined SOPs and most studies can be conducted under GLP compliance if required. The range of services offered at Southern Research meets the highest scientific standards, and we are committed to achieving cost efficiency and timely study completion to support client needs.

In vitro anticancer efficacy capabilities include:

• Drug-drug and drug-radiation combination and scheduling studies
• 60 cell-line panel cytotoxicity testing
• Extensive panel of more than 200 human tumor lines, including drug resistance models
• Custom assay and method development
• Quantitative dose-response analysis of growth inhibitory activity or cytotoxicity
• Cell cycle analysis
• Apoptosis measurements
• Angiogenesis assays
• Mechanism of action
• Signal transduction studies
• Biomarker analysis
• Flow cytometry
• Gene and protein expression
• Enzyme and receptor binding assays
• Imaging and cellular localization
• In vitro myelotoxicity assessment
• Normal cell models, including primary cultures
• Immunohistochemistry and related methods
• Hollow fiber screening assay
• Caco-2 assays
• Drug uptake/retention studies

Publications